GUISLA SCHAFSTELLAR: The medications have very much kept his self-esteem up and going. Without it, I don't think he would be in the mental frame of mind that he is still in. Being upbeat, having a good sense of humor and tackling things that he enjoys doing.
ANNOUNCER: While the medications have been effective, there are possible side effects.
MATTHEW B. STERN, MD: These are troubling involuntary movements, where patients will develop hyperactive movements in response to l-dopa or another phenomenon we refer to as the wearing-off effect. Patients will feel a good response for a period of time, the response will run out and the patient will turn off and develop their symptoms again.
One of the strategies in dealing with patients who have wearing-off effects or these motor fluctuations has been to try and develop ways of smoothing out the delivery of l-dopa. And one way of accomplishing that is to try and interfere with its metabolism in the body and we know, for example, that there are several enzymes that break down levodopa in the body and we've developed compounds that can actually interfere with that process.
ANNOUNCER: Helmut, a retired engineer, leads an active life with his wife Guisla.
HELMUT SCHAFSTELLAR: I try to ignore the damn thing. I still play tennis three times a week. We do some bicycle, weather permitting, once a week. I can do just about anything I need to do, except it takes ten times as long.
ANNOUNCER: Sometimes Helmut needs help, so Guisla has had to adapt too. As caregiver she assists with a button, a meal, whatever needs to be done.
